An experimental cancer drug emerges to have cured every patient in a small clinical trial conducted in the US. The 12 patients who had been diagnosed with rectal cancer entered remission after taking Dostarlimab for over six months. This is indeed the first time in history that has happened. So, First Time In History Cancer Disappears For Every Patient In Drug Trial.
Although the patients also experienced no significant side effects during their medication, there were not enough people involved in the study to highlight the different adverse reactions that the drug can cause. However, scientists have expressed the promising results will need to be repeated and cautioned against concluding that cancer has been eradicated permanently.
Dostarlimab is an immunotherapy drug used to treat endometrial cancer. This was the first clinical examination into whether it could be effective against rectal cancer tumors. The drug works by unmasking cancer cells. It allows the immune system to identify and destroy them. The 12 patients got Dostarlimab every three weeks for six months for the research.
However, this medication had disappeared after six months of treatment, when the patients stopped taking it, being undetectable by physical exam, endoscopy, PET, or MRI scans. Two years after the research, the patients is to remain cancer disease-free, and none of the patients in the trial have yet received chemoradiotherapy or undergone surgery.
All 12 patients in the study had tumors with a genetic mutation, also known as Mismatch Repair Deficiency (MMRd). It is seen in a subset of approximately 5 to 10% of patients with rectal cancer. Patients with such tumors tend to be less responsive to chemotherapy and radiation treatments, increasing the need for surgical removal of their tumors.
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